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This is probably due to both the restricted access to most tissues in humans and the complex nature of exercise that involves many organ systems that are linked via the increased metabolic requirement of contracting skeletal muscles

Chem Rev 116(5):30293085

Adv Med Sci

Further, NOX2 depletion and the NOX inhibitor apocynin were able to reduce NF-KB activation, demonstrating how ROS can lead to the increased expression of proinflammatory cytokines (Shekh-Ahmad et al., 2019, 2018)